Harvard Alumni Magazine  [Printer-friendly version]
March 3, 2006


Sibling specialists attack the political and economic causes of health

by Madeline Drexler

In the city of Boston -- and everywhere else -- wealth equals health.
If you live in Beacon Hill's Louisburg Square, which sits in the
federal census tract with the third highest median family income in
Suffolk County -- $196,210 -- you're sitting pretty. Your risk of
dying before the age of 65 is about 30 percent less than if you live
on Pleasanton Street in Roxbury, about four miles away, where the
median family income is $30,751, and where one-third of residents live
(or more accurately, survive) below the poverty line. Put another way,
Louisburg Square's red brick and brownstone, lovingly maintained
locusts and beeches, wrought iron gates and sparkling windows with
wavy glass exert a measurably salutary effect on the human body.
Pleasanton Street and its environs -- home to dilapidated Victorians
and untended maple trees, abandoned lots and overflowing dumpsters,
shards of automobile glass and billboards that say "Looking to Re-
Establish Credit? We Finance Anyone" -- in effect act like a potent
risk factor for a spectrum of ills.

Two years ago the New England Journal of Medicine published a
commentary titled "Class -- The Ignored Determinant of the Nation's
Health." Its authors, a policy analyst and an academic physician,
wrote: "[P]eople in lower classes die younger and are less healthy
than people in higher classes. They behave in ways that ultimately
damage their health and that take their lives prematurely (by smoking
more, having poorer eating habits, and exercising less). They also
have less health insurance coverage, live in worse neighborhoods, and
are exposed to more environmental hazards. Beyond that, however, there
is something about lower socioeconomic status itself that increases
the risk of premature death."

For 20 years, that "something" about being poor and getting sick has
preoccupied Nancy Krieger '80, Ph.D., professor of society, human
development, and health at the Harvard School of Public Health. It has
also preoccupied her older brother, James Krieger '78, M.D., chief of
the epidemiology, planning, and evaluation unit at Public Health-
Seattle and King County, his local public-health authority.
Independent of each other, the Krieger siblings have transformed that
fixation into the leading edge of public-health theory and practice.
Nancy's hypotheses and methods are called, by many colleagues, the
most brilliant contributions to social epidemiology in a generation.
Jim's on-the-ground innovations are the envy of local health
departments across the country. Sister and brother have set a standard
for what public health can and should be in the United States; both
are trying to steer the profession back to its roots in social
justice. That few beyond their respective fields have heard of the
Kriegers says as much about their modesty as about the battered
profile of public health in America.

Public health is dedicated to the humble proposition that social
action to promote health and prevent disease saves more lives more
cheaply than does high-tech medicine. Recently, U.S. health
authorities have paid some lip service to this perspective. In
scientific meetings, official reports, and federal financing, the
terms "health disparities" and "social determinants of health" have
cropped up. In 2006, the National Institutes of Health will allot $200
million (out of a total budget of $28 billion) for its Center on
Minority Health and Health Disparities. Here's the main idea behind
the terms: the immediate causes of individual human affliction, parsed
ad nauseam by newspaper and magazine health-advice columns -- fatty
diets, tobacco smoke, sedentary ways -- are themselves caused by
underlying forces: poverty, discrimination, stressful jobs, marketing
by profit-driven global food companies, substandard housing, dangerous
neighborhoods, and so on. Put another way, if every human being
enjoyed all life's opportunities, disease patterns would look very

What makes the Kriegers' work unique is that they have toiled in
vastly different domains but toward the same goal of understanding the
social determinants of health, starting long before the phrase
acquired professional cachet. They have proven that these
institutional precursors are as amenable to study as any single-celled
bacterium -- and not only to study, but to change.

Though only 47, Nancy Krieger has published empirical papers,
theoretical treatises, and historical essays that have shaken her
field. Her work is technically complex, but the main premises are
simple: Racism and social class indelibly stamp disease across
populations. These forces stemming from the body politic can be
dissected every bit as sharply as the body itself. The political and
economic structures that prop up race and class differences in health
should be named and blamed. "She burst on the scene like a comet, with
tremendous intellectual firepower and passion," says Sherman A. James,
professor of public policy studies and community and family medicine
at Duke University.

In 1986, in the middle of Ronald Reagan's second term, Krieger and her
coauthor, physician and public-health researcher Mary Bassett,
published a paper titled "The Health of Black Folk: Disease, Class,
and Ideology in Science." It argued that the higher premature death
rate among blacks, compared to whites, wasn't due to the victims'
genes or lifestyle choices, as the conservative line of the time
insisted, but rather to the overwhelming circumstances of their lives
since birth. To comprehend how jarring this assertion was, consider
the statement in a leading epidemiology textbook, published the same
year, that "social class is presumably related causally to few if any

In the 20 years since, Krieger has shown that social class and racism
are related causally to the leading sources of illness and death in
the United States. Those overarching social forces remain the focus of
her curiosity.

Last November she brought her ideas to the REACH Boston Elders 2010
coalition, a group of community advocates, retirees, and citizens
concerned about health issues. Traveling from their homes and
apartments in the mostly black neighborhoods of Dorchester, Roxbury,
and Mattapan, they meet each month in a function hall at the golf
course in Franklin Park. It is the kind of event Krieger relishes,
because it plucks her out of academia and drops her in a world where
her work could make a difference. Her attire reflected her self-
identity as someone outside the academic mainstream: a man's oxford-
cloth shirt that billowed out, with sleeves rolled up (because she is
five feet two); cargo pants; a dark vest; a fedora when she was
outdoors. Her short black hair, flecked with gray, was combed back.
Rimless glasses perched in front of expressive dark eyes.

The Boston Elders' director, April Taylor, a tall, high-spirited
woman, was excited to greet Krieger. "I've followed Nancy's work for a
long time," she said. "Isn't that crazy? To say you love someone's

Though Krieger began her speech on a personal note -- "Think for a
moment about the stories our bodies tell," she said -- she soon took
up more weighty matters. Midway through, she flashed a chart titled
"The Jim Crow Effect: Temporal Lags in Black/White Disparities in Life
Expectancy: United States, 1900-2000." Jim Crow laws, in effect from
the 1880s to the 1960s, enforced racial segregation in marriage,
public facilities, and virtually every realm of life. Krieger's slide
showed that in each year of the last century, by depressingly fixed
margins, blacks lived shorter lives than whites. In 2000, the life
expectancy of blacks equaled the life expectancy of whites in 1960.
Today, U.S. blacks live an average of 71 years, while whites live 78
years. The first generation of African Americans to be born post-Jim
Crow is only 40 years old. "This means that people born before the
1960s, including you, carry within their bodies the history of the Jim
Crow era," Krieger explained.

The room got quiet.

Another slide showed a census tract map of Boston, with rising
proportions of "excess" premature mortality -- shown in deepening
shades of red -- in lower-income districts, compared to the richest
census tracts. In essence, the map portrayed the economic geography of
early death. Krieger cited a figure known euphemistically as the
"Population Attributable Fraction," or PAF, of premature mortality due
to census- tract poverty. Translated, it says that 30 percent of those
who died under age 65 in the city's poorest areas would still be alive
if the premature death rates in their neighborhoods had been the same
as those in Louisburg Square. Though researchers have used the PAF for
decades to examine a variety of exposures and outcomes -- from smoking
and death rates to high cholesterol and heart disease -- Krieger was
the first person to calculate the PAF for poverty and premature
mortality in Boston -- or to think about calculating it. "Thirty
percent is a pretty stark contrast," she said.

"Sure is," said a man in the back. "If the white folks moved to the
black areas, would they die any earlier?"

"That's a great question," Krieger said. "If they were born and lived
under the same conditions as the African Americans living in those
neighborhoods, they would have a worse mortality rate as well."

A woman raised her hand. "This report is very good and honorable," she
told Krieger. "Who do you give this report to?" Though Krieger didn't
elaborate, the answer is: to a peer-reviewed scientific journal, with
the hope that subsequent publication and media publicity will compel
health officials, lawmakers, and advocacy groups to do something.

During the past 20 years, for reasons that remain unclear, asthma
rates have steadily crept up in the United States. The disease is
chronic and often unbearable: muscles of the bronchial tubes tighten
and thicken, air passages become inflamed and mucus-filled, and the
victim coughs, wheezes, and ultimately gasps for air. The most common
asthma triggers are well-known: mold (from dampness and poor
ventilation), dust mites (from old carpeting and unwashed linen),
cockroaches and rodents (from infestations in dilapidated homes),
tobacco smoke, toxic indoor chemicals, and ozone and diesel
particulates in congested urban areas. This list explains why the
disease disproportionately strikes poor people and minority
populations. In King County, Washington, children from low-income
neighborhoods are three times more likely to be admitted to the
hospital for asthma than children from well-heeled communities.

Jim Krieger is a slight man, his expression reflective yet impish,
wire rims resting on an aquiline nose, gray-tipped beard on sunken
cheeks. His most conspicuous feature, though, is his soft voice: so
light, high-pitched, airy with a slightly metallic sibilance, that one
must and one does pay attention. In the mid 1990s, he hatched a plan
to reduce Seattle's asthma rates. The idea was both bold and
calculated. He would take on the "social determinants" behind this
major public-health challenge -- but he wouldn't call it that. The
phrase "social determinants," after all, was too ponderous, too
accusatory, too lefty, to play well with policymakers. Nor did it play
well with the minorities and low-income residents who were the actual
victims of harmful environments. "You can't approach them and say,
'Let's work on social determinants of health,"" Jim says. "Instead,
start with what they're concerned about -- which is, they can't
breathe -- and then find the social determinants that affect asthma.
Work the issue that way. Back into it."

At the time, asthma was the "disease du jour." A wealth of data proved
it was increasing, which caught the attention of politicians and
health officials. It also helped that most people intuitively
understood the connection between housing and health, thanks to
nineteenth-century campaigns to control typhus, tuberculosis, and
other infections by improving sanitation and living arrangements. And
so, beginning in the late 1990s, Seattle's Healthy Homes project
received hefty grants from federal and private sources.

The program rested on an approach known as community-based
participatory research. Newly minted health workers, who lived in the
affected areas and often suffered from asthma, or had family members
who did, went house-to-house to educate their neighbors about how to
take care of themselves. Krieger's project demonstrated that children
from those families who received frequent visits and intense education
from health workers spent fewer days with symptoms and took fewer
trips to the emergency room. The families learned about taking
medicine properly and cleaning up their homes, but also got material
help: allergy-control bedding, low-emission vacuum cleaners with
microfiltration bags, cleaning kits, roach bait, and rodent traps. The
community workers, meanwhile, collected reams of data on the problems
they encountered and the results of their interventions, to meet the
highest standards of scientific investigation.

The results were dramatic. In King County, the asthma hospitalization
rate for children had increased 57 percent from 1987 to 1995. Between
2000, when the community health workers marched into action and the
health department bolstered asthma prevention in schools and clinics,
and 2004, the rate declined 39 percent.

In 2003, Krieger received an Innovation in Prevention Award from the
U.S. Department of Health and Human Services. There was irony in his
selection. Then-HHS secretary Tommy Thompson had long promoted
policies, such as giving obese citizens pedometers to count their
daily steps, that were diametrically opposed to the social-determinant
model Krieger favored.

All along, Jim Krieger assumed that Healthy Homes was merely a first
step toward solving asthma. Until he began addressing fundamental
social determinants of the disease, he wouldn't make much difference.
In 2002, his interest and that of the city's public-housing agency
coincided. The Seattle Housing Authority (SHA) began sketching out an
unprecedented vision. High Point, in West Seattle, then consisted of
barracks-like single-story structures originally built as temporary
dwellings for Boeing workers after World War II. Sixty years later,
buildings designed to last five years had become decrepit public
housing. Not surprisingly, 10 to 12 percent of residents had asthma.
The SHA determined to tear down the old structures in two phases, the
first of which ended last fall. (Affected residents, who were
relocated to other public housing in the city, were guaranteed a unit
in the new site.) Replacing the old project would be a handsome,
mixed-income community spread over 34 city blocks: green, sustainable,
walkable, with expansive parks and majestic old trees, capacious front
porches to deter crime, and a street grid connected to the rest of
funky West Seattle. It would also include 35 allergy-free townhouses
for people with asthma.

When the Housing Authority asked Krieger if he would be interested in
the project, "he leapt at it," said Tom Byers, a well-connected local
Democrat and partner in a consulting firm, Cedar River Group,who
helped shepherd High Point to completion. Byers had made the initial
phone call to Krieger. "He said: 'Oh yes, that sounds very exciting.
Now, we'd have to look out for this, and we'd have to look out for
that. And we will probably need to build a minimum of 60 homes to make
the data reliable."" For a public-health warrior like Krieger, it made
no sense to build designer homes for a small group of impoverished
asthma sufferers without a study large enough to offer statistical
proof of the homes' benefits. If the project panned out, Krieger hoped
to see the concept replicated throughout Seattle's low-income
communities -- and beyond. "He's the people's epidemiologist," Byers

The Breathe Easy units, as they came to be called, are a state-of-the-
art response to asthma sufferers imprisoned in bad homes: a direct
cure for a deleterious social determinant of health. For about $5,000
extra in construction costs per unit, they are outfit-ted with
filtered ventilation systems, insulated foundations, moisture-removing
fans, cherry cabinets free of asthma-triggering glues, low-outgassing
paints, easy-to-clean Marmoleum floors -- and even landscaping with
low- allergenic plants.

Lanh Truong and her two sons were the first to move into a Breathe
Easy unit, in December 2005. A meticulous, effervescent 25-year-old,
Truong had escaped as a child from Vietnam to a refugee camp in
Thailand, eventually landing in Seattle. She earns $9 an hour pouring
wax for decorative candles. Two years ago, her younger son, Steven,
now four, was diagnosed with serious asthma after repeated trips to
the hospital emergency room and the local health clinic. At the time,
Truong and her boys were living in the original High Point project.
"Mold and too dirty and too old," Truong said of her former home.
"Mold on the ceiling. When I clean them, they come back."

"I heard they were building a new house," she said. "Easy for the kid
to breathe. I love it. I want it. Because I don't want my kid to be
more sick." And though she herself was never officially diagnosed with
asthma, she has noticed that she feels better, too. "When I get into
the house, easy for breathing."

Jim Krieger may have overseen construction of the Breathe Easy homes,
but the idea originated with a tenant leader and former president of
the local community council, Bonita Blake. Before chronic respiratory
illness and a car accident disabled her, Blake had been a professional
opera singer. Like many leaders in poor communities, she was wary of
outsiders who wanted to study her neighborhood's problems and impose
their own solutions. But she trusted Krieger. "I just love him," she
said. "He spoke gentle to us, with us, on behalf of us. He didn't make
us feel guilty or lesser than -- I had expected him to do that. I
wasn't so much hearing what he said as much as I heard his heart. He
believed in what he was saying. He had a great cause -- and he was
committed to that cause."

How did two siblings like Nancy and Jim Krieger evolve? They grew up
on East 96th Street and Fifth Avenue, on the borderline between the
Upper East Side of New York City and Spanish Harlem, an urban
demarcation where the statistical link between poverty and early death
surely resembled that between Louisburg Square and Roxbury. Steps from
Mount Sinai Hospital, their apartment building sat on a city block
that boasted the highest concentration of physicians in the world. Two
of those doctors were their parents, Dorothy Terrace Krieger, director
of the Mount Sinai School of Medicine's division of endocrinology and
recipient of a special award in 1984 from the Lasker Foundation, and
Howard P. Krieger, chair of the neurology department at Beth Israel
Medical Center as well as a teacher and researcher. Dorothy Krieger, a
driven, artistic, deeply private woman, was considered the
intellectual powerhouse of the two. A Barnard College graduate at 18,
she was gifted enough to have considered a career as a classical
pianist. Scientific competition and other issues eventually corroded
the marriage. The Kriegers divorced when Nancy and Jim were in
college, and Dorothy Krieger remarried. She died at 58 of breast

Nancy and Jim grew up with a regimen of elite schools and directed
study. Knowledge was meant to benefit the world; medicine was
understood to be the noblest profession. Dinnertable talk centered on
school, current events, and hospital politics. "Any topic could be
discussed. It was very verbal. But you had to make your case --
opinions were not sufficient," Nancy recalls. "I wouldn't say the
inculcation was completely enjoyable."

From the start, sister and brother struck out in different directions,
a reflection of their personalities. Nancy was solitary, inward, and
fiercely strong-minded. At six and a half, according to Dorothy
Krieger's notation in a baby book, Nancy was "vacillating between
believing in God, because 'doesn't want to be different," and not
believing because of scientific evidence of process of geology and
evolution." It may have been the last time Nancy vacillated, or feared
being different.

As a Harvard undergrad concentrating in biochemistry, Krieger consumed
a heady brew of Marxism, feminism, evolutionary biology, history, and
campus activism. She came out. She also plunged into experimental
theater, doing tech work for classmate Peter Sellars, the avant-garde
director, whose work at the time she considered insufficiently
political. "We fought a lot," she said. "We also talked about the
nature of theater -- making dead things come alive -- because we both
had interests in the classics as well. I love the world of the
theater, and I love the world of making things happen." After
graduation in 1980, she moved to Seattle, where she started to make
things happen in an unexpected sphere. It was a shock to the family
system when Nancy announced that she would pursue graduate work in
epidemiology -- "The only time my mother hung up on me. If you're at
the center of academic medicine, public health looks like less than
the last hair on the tail of the dog."

Her University of Washington master's thesis analyzed the effect of
class position on breast-cancer survival. In 1988, she wrote
presidential candidate Jesse Jackson's AIDS platform. At the
University of California, Berkeley, where she earned her doctorate in
1989, she peered across the landscape of women's social roles to
explain why breast cancer is more likely to strike black women under
age 40, but more likely to strike white women after 45. Until then,
researchers had assumed that racial differences in breast-cancer risk
were just that: racial. Krieger focused on class standing and its
influence on educational level, fertility rates, abortion, oral
contraception, and other seeming imponderables. "For Nancy to look
beyond the usual cast of characters, to think about it more broadly,
was remarkable," says S. Leonard Syme, professor of epidemiology and
community health at Berkeley's School of Public Health. "It put breast
cancer in the middle of social process."

On the day Krieger was scheduled to deliver her doctoral defense, an
event usually sparsely attended, the faculty filed in to hear her. "We
couldn't get a room big enough," recalls Syme. "People were sitting on
the floor and on the windowsills."

"They knew this was a voice they had to listen to, whether they liked
that voice or not," adds Meredith Minkler, now a professor of health
and social behavior at Berkeley. "Nancy talks very fast. People
shouted out: 'Slow down!' We were scribbling notes as fast as we
could, because we didn't want to lose any of it."

A year after being awarded her Ph.D., during which time she became an
investigator at the Kaiser Foundation Research Institute, in Oakland,
Krieger returned to Berkeley to deliver the commencement speech. "On
Becoming a Public Health Professional: Reflections on Democracy,
Leadership, and Accountability" is required reading in many public-
health courses around the country. In it, Krieger asks: "Are the
'experts' all white? Are they all men? Are they all affluent? Are they
all straight? If so, we have a problem."

That made her appointment at Harvard, where she joined the faculty in
1995, all the more arresting. She continues to dress in a provocative
way -- that is, her version of provocative. "For the first several
faculty meetings, I made sure to wear a tie." Krieger's annual course,
"History, Politics, and Public Health: Theories of Disease
Distribution and Social Inequalities in Health," is regularly
oversubscribed. Last year she was awarded tenure, an academic
vindication for public-health progressives. As one colleague
proclaimed at Krieger's tenure party, holding aloft a glass of
champagne: "Every once in a while, justice triumphs."

In his youth, Jim Krieger created a rich friendship network outside a
home oriented 100 percent to scholarship. He committed the apostasy of
joining his high school's swimming and soccer teams. And long before
his coalition work with asthma, he made a point of meeting people
where they were, by fitting in with different cliques: the academic
aces, the jocks, the politicos, and the cool crowd. "It was curiosity,
more than anything else. I always saw myself as someone who bridged
different cultures."

He also took up photography and joined classmates in a group called
the Saturday Housing Project, wielding a Nikon to document shocking
conditions in Harlem and the Bronx. The students submitted their
reports and pictures to tenants-rights organizations, which used them
to argue for repairs. "I remember one bathroom where the toilet wasn't
working, lime green peeling paint coming down all over the place, one
bare light bulb hanging from the ceiling," Krieger said. "The shower
was rusty and not working very well, and there was a big leak in that
bathroom. It was the only bathroom in a house for six or seven people.
Here I was living in an apartment off of Fifth Avenue, and this was
less than a mile away."

The Saturday Housing Project was a "shaping experience," he said,
sowing "a set of core values that I still have to this day: of
addressing social inequities in an activist, concrete, doing kind of
way." Advocacy, he saw, produced results. "Some of the clients that we
worked with were able to force the landlords to make improvements.
[In] other cases, in which the association couldn't do anything, we
were able to assist the family in finding better housing or getting
them onto public housing."

At Harvard, where, like Nancy, he concentrated in biochemistry,
Krieger protested against apartheid in South Africa. After graduating
in 1978, he joined VISTA to work on health, school, and housing
issues. A chance conversation with an activist physician convinced him
that he could do more good working inside the establishment than by
knocking on the doors of Somerville triple-deckers. Yet in 1983, he
took a year off from his medical school residency at the University of
California, San Francisco, and headed to Nicaragua, where the
Sandinista revolution had exploded. It was his final transformative
push into public-health activism. He toiled in a tiny four-room clinic
set in the middle of a sugar-cane plantation. During the day, women
and children with anemia, respiratory infections, and intestinal
parasites filled the waiting room. At night, men trudged in from the
fields with machete wounds. Krieger was swept up in a health
revolution, where a nation untouched by the most basic public-health
measures was suddenly the target of childhood immunization campaigns,
life-saving oral rehydration for deadly diarrheal infections, and
other enlightened practices imported by politically impassioned young
doctors from the rich world -- people like Krieger.

"If you have a transformative period in history like that, where
political forces are lined up with social forces," he says, "then you
can make profound change. That gave me a vision about the way things
could be. But also it helps me understand better the realities of the
last 20 years, which has been a conservative period in our country's
history." In Seattle, his solution has been to embark on smaller-
scale, incremental projects, with the hope that the pendulum will
eventually swing and make way, if not for revolution, then for
accelerated evolution.

Nancy Krieger says she gets many of her insights when engaged in
intellectual debate with someone: either in person, or in her head. In
a sense, the scrupulous logic and extensive footnoting in her papers
may be the legacy of her childhood dinner-table discussions. Today,
walks around Jamaica Pond are a reliable source of inspiration. In her
left shirt pocket, a small pad of paper and three pens are always at
the ready. "I don't like to travel," she said. "But my mind likes to

Mostly, it has traveled over uncharted intellectual terrain. Beginning
in 1990, Krieger was the first scientist to describe how racial
discrimination harms physical health -- by explicitly measuring
exposure to racial discrimination and testing its association with
high blood pressure. "She did things that made some of the leading
people in the field quite uncomfortable," says Duke's Sherman James.
"But she did it so brilliantly that people who are made uneasy by her
intellectual challenges could not fault her on the grounds of sloppy

Traditionally, epidemiology "adjusted" for race and class: using
statistical sleight of hand, it erased the overwhelming effects of
racial discrimination and poverty on populations in order to flush out
the specific biological pathways behind disease. Krieger said that
race should not be treated as a background influence or biological
risk factor to be controlled for, but rather that racism should be
analyzed as a causal exposure for disease in its own right. She wanted
to measure the effects of discrimination, poverty, and injustice on
health directly.

In 1996, Krieger published the first, and still largest, study to
suggest that bearing the brunt of racial discrimination raises the
risk of elevated blood pressure, a partial explaination of why blacks
suffer more hypertension than whites. She showed that racial
discrimination is just as harmful as any of the usual culprits: lack
of exercise, smoking, a high-fat or high-salt diet.

"It was controversial," says James. Although the statistical outcomes
were surprising, they were also nuanced. "The findings were very
complex -- and a lot of people have difficulty dealing with that kind
of complexity." Even more noteworthy, the paper was based on data
collected in one of the gold-plated studies in the history of
epidemiology: the Coronary Artery Risk Development in Young Adults
(CARDIA) study. The analysis was not only a technical tour de force,
but a red flag for critics, who charged that her conclusions went
beyond the evidence.

To answer them, Krieger developed a scientifically validated research
instrument for measuring people's experiences of racial discrimination
-- one now used by researchers studying a wide array of health
outcomes, from hypertension to tobacco use to depression. And she
continued to ponder the deeper meaning behind the data, including the
hint that repressing the anger and humiliation of racial
discrimination exacts a physical toll. "The evidence is there in the
bodies, but people can't say, at times, what happened to them," she
says. "That's what solidified for me the idea that bodies can tell
stories that people sometimes can't, or won't, or aren't able to, or
are not free to tell."

In the late 1990s, Krieger set out to devise a method to portray the
link between a community's health status and its socioeconomic class.
She was building on work she had started as a master's degree student
in 1984, frustrated by the dearth of socioeconomic data in U.S. health
records. The Public Health Disparities Geocoding Project, launched in
2004, is a major advance in public-health research. (Its methods are
freely available at www.hsph.harvard.edu/thegeocodingproject.) Though
the technical details are complicated, Krieger's concept boils down to
this: one's street address turns out to be a pretty good indicator of
one's health. Within a federal census tract (an area that usually
includes about 4,000 people of similar income and living conditions),
the poverty rate corresponds closely with residents' health status.

Krieger's linkage of census data with public-health surveillance
information helps officials track whether the health gap between rich
and poor is getting smaller or bigger, or whether government policies
are making the situation better or worse. It also flushes out small,
often overlooked, pockets that may need extra attention. Health
departments from Boston to Brazil, from China to Costa Rica, are using
her techniques. "I'm sitting here in the health department, and I want
her to teach me," says Bruce Cohen, director of the division of
research and epidemiology at the Center for Health Information and
Statistics at the Massachusetts Department of Public Health. "I want
to be able to replicate what she does, with fewer resources than she
has, so I can use our data to identify target populations for our
programs more effectively."

In 2000, Krieger published the first U.S. study to calculate on a
state-wide level how poverty raises the risk of becoming infected with
the AIDS virus. "Partly as a result of the research that Nancy has
done, we have been able to make the case that the number-one public-
health issue in Boston is racial and ethnic healthcare disparities,"
says John Auerbach, executive director of the Boston Public Health
Commission. "Several years ago, we would never have been able to make
that case."

More recently, Krieger has used geocoding to paint a fine-grained
portrait of preventable suffering. In Massachusetts and Rhode Island,
she showed that more than half the cases of childhood lead poisoning,
sexually transmitted infections, tuberculosis, nonfatal gun-related
injuries, and HIV/AIDS deaths among the poorest residents would not
have occurred if their risk had been the same as that of people living
in the wealthiest enclaves.

Yet Krieger's theoretical papers may be even more influential. Most
epidemiology theory comes from the grand old men of the profession, at
the end of storied careers. Krieger began penning her decidedly
unpontifical ideas in her thirties. The most famous was published in
1994: "Epidemiology and the Web of Causation: Has Anyone Seen the
Spider?" Drawing deeply on history and philosophy, the article in
Social Science and Medicine dismantles the central tenet of modern
epidemiology: the belief that population patterns of health and
disease spring from a complex (and rather gauzy) "web" of risk and
protective factors. Krieger suggests the web approach is both short-
sighted and cowardly because it focuses on individuals and ignores how
and why diseases vary and shift across populations and over time. It
looks at lots of narrow mechanisms and not at the overarching forces
that set those mechanisms into play.

Instead, she asks, "Who or what is the 'spider?'" What societal forces
create the risk factors that eventually sift down to the organs and
cells and DNA in our bodies? And how are those forces sowing disease
across populations? "When you look at it after reading it, you say: Of
course. But no one really saw it until then," says her former Berkeley
mentor Len Syme. "Everywhere I go in the world, I see that paper
sitting on people's desks."

In the "Spider" paper, Krieger also introduced "ecosocial theory,"
which ties together many of her intellectual insights. She argues that
an individual's health can't be torn from context and history. We are
both social and biological beings, she says -- and the social is every
bit as "real" as the biological. Society, in fact, intimately connects
with biology from the moment we are born -- or even before. Explaining
the comparatively high risk of hypertension among African Americans,
Krieger wrote: "A person is not one day African American, another day
born low birth weight, another day raised in a home bearing remnants
of lead paint, another day subjected to racial discrimination at work
(and in a job that does not provide health insurance), and still
another day living in a racially segregated neighborhood without a
supermarket but with many fast food restaurants. The body does not
neatly partition these experiences -- all of which may serve to
increase risk of uncontrolled hypertension."

Understanding the deepest roots of disease, in Krieger's universe,
requires asking questions about social structure, cultural norms,
ecologic milieu, and genetic variability -- not piecemeal, but all at
once. In a 2004 study, for instance, Elizabeth Barbeau, director of
tobacco-control research at Boston's Dana-Farber Cancer Institute,
found that class strongly influences the likelihood of giving up
smoking -- the very kind of role Krieger's theories would predict.
"People in working-class occupations actually attempted to quit just
as often as people in higher occupational groups. But they were not as
successful in doing so," Barbeau explains. Why not? Maybe because they
didn't have health insurance to pay for nicotine patches or smoking-
cessation counseling. Or because their workplaces still permitted
smoking. Or because their jobs were so monotonous that lighting up was
the only way to break the tedium.

Or take San Francisco bus drivers, 90 percent of whom suffer
hypertension by age 60, not to mention lower back pain, respiratory
disease, gastrointestinal distress, and alcoholism. "At some point you
have to say, 'Wait a minute. Where's the spider?'" says Len Syme. "The
fundamental, underlying problem is a job that is causing a higher rate
of everything." In this case, Krieger's hypothesized arachnid was a
rigid and arbitrary schedule that drivers could not humanly keep up

In the late 1990s, pundits from several conservative think tanks
launched incendiary salvos against Nancy Krieger's work. They argued
that her research undermined Americans' cultural beliefs in self-
reliance. Typical was lawyer Heather MacDonald's 1998 article "Public
Health Quackery," in the Manhattan Institute's City Journal: "Behind
all their talk of racism and sexism, Krieger and her colleagues' real
prey is individual responsibility. Traditional epidemiology looks at
both individual risk behaviors and the environment to determine the
source and pattern of disease. But the modern miasmaticians assert
that to study individual risk factors, such as drug use or smoking,
'blames the victim' -- at least when that victim is poor, female, or
black. When such victims get sick, society is to blame. And so the
public health revisionists are generating a remarkable body of excuses
for the most avoidable and dangerous behaviors, particularly those
relating to HIV/AIDS."

Eventually the attacks fizzled out, most likely because Krieger built
a massive foundation of empirical research and methods to support her
vaulting theories. "I was going to do this work. Or I was not going to
be allowed to do this work. But I wasn't going to do something else,"
Krieger says. "It's very clear that you could only get away with this
stuff if you're really good. This is not about doing 'politically
correct' science: it is about doing correct science."

In January, Jim Krieger returned to Seattle from a month's hiking in
the Andes with his partner, Kim, a public-health program director. As
it happened, Nancy was also in Seattle, en route to a talk in
Vancouver. At dinner, over pasta and wine, the siblings' resonant
lives and divergent personalities were on display. Nancy radiated a
feeling of deep stillness, even when she was in motion. Jim exuded a
coiled kinetic energy, even when sitting still.

The family dynamic, they agreed, was complicated. Although Nancy was
encouraged to pursue any interest, Jim was explicitly pointed toward a
medical-research career. During a high-school summer science camp, his
parents were disappointed that the program wasn't demanding enough.
"They told me I was wasting my time," he recalls, "not doing good
enough experiments." As if reliving the experience, Jim shifted to the
present tense. "You prove your value through your intellectual
achievements. They don't give you attention, affection, love, whatever
-- you have to earn it."

By happenstance or by design, sister and brother ended up in the same
profession, fighting the same villains, doing like-minded but unalike
work on opposite coasts. Were they competing, or avoiding competition?
Both said that even though the competitive bait had been set at an
early age, they didn't bite. "The intellectual was the easy part,"
Nancy said. "Much more difficult was the emotional part. There was a
very limited amount of parental attention to go around, and there was
competition for that. You can't win that competition. You can live it
-- but nobody wins, and everybody loses."

Despite that awareness, Nancy and Jim never lost their emotional

The next day, during a walk around Phase I of the new High Point, the
cool air rang with a medley of contractors' saws and nail guns. To the
west stood the gray-green, snow-capped Olympics hovering over Puget
Sound. To the east, the Cascades. In every block Jim noticed little
improvements since he'd last seen the grounds: new plantings,
drainpipes, paths cleared through the woods. "This is really looking
good," he said. Nancy's mind was churning with political questions:
the power shifts that had permitted such handsome housing for poor
people, how different ethnic groups would or would not coalesce in the
new community. She also felt a sense of possibility.

Earlier, Nancy had said that Jim's work was a "touchstone" for her.
"I've always looked up to my brother. I think he's principled. He's
displayed political acumen. And he's pushing the edges of what a
health department can do."

Similarly, Jim had said, "I like reading what Nancy writes. It's
important for people in public health to have theoretical constructs,
big-picture vision. It can be very motivating, morale-building. You
feel you're plugged into something bigger than you are."

Strolling past freshly painted townhouses, Nancy told Jim she was
proud of him. He accepted the compliment -- he's been getting better
at accepting compliments -- but reminded her that it wasn't just him,
that lots of people were involved. She said, "Still, here it is."

Boston-based journalist Madeline Drexler is the author of Secret
Agents: The Menace of Emerging Infections (Penguin). She has a
visiting appointment at the Harvard School of Public Health.

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